X0306 4 2018-11-30 0 0001461993 MELINTA THERAPEUTICS, INC. /NEW/ MLNT 0001237257 DOWNEY BRUCE C/O MELINTA THERAPEUTICS, INC. 300 GEORGE STREET, SUITE 301 NEW HAVEN CT 06511 1 0 0 0 Stock Option (right to buy) 2.12 2018-11-30 4 A 0 25000 0.00 A 2028-10-31 Common Stock 25000 25000 D One-third of the shares underlying the stock option will vest and become exercisable on October 31, 2019. The remainder will vest and become exercisable in substantially equal monthly installments during the two year period commencing on October 31, 2019. /s/ Russ Causey, by Power of Attorney 2018-12-03