X0306 4 2020-09-11 0 0001159036 HALOZYME THERAPEUTICS, INC. HALO 0001236537 MATSUI CONNIE C/O HALOZYME THERAPEUTICS, INC. 11388 SORRENTO VALLEY ROAD SAN DIEGO CA 92121 1 0 0 0 Common Stock 2020-09-11 4 S 0 32000 27.056 D 216753 D Common Stock 2020-09-14 5 G 0 E 8000 0 D 208753 D Represents a weighted average sales price per share. These shares were sold at prices ranging from $26.95 to $27.16. The Reporting Person has provided to the issuer, and will provide to any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. Represents a bona fide gift to a charitable organization. /s/ James R. Oehler as attorney-in-fact for Connie Matsui 2020-09-14