X0609 4 2026-04-20 0001228627 Opus Genetics, Inc. IRD 0001236365 MANUSO JAMES S J false C/O OPUS GENETICS, INC. 8 DAVIS DRIVE, SUITE 220 DURHAM NC 27713 true false false false false Common Stock 2026-04-20 4 A false 24367 0 A 317318 D Represents a grant of restricted stock units which vest upon the earlier of the one (1) year anniversary of the grant date or the day prior to the Issuer's next annual meeting of stockholders occurring after the grant date, subject to the Reporting Person's continuing service through the vesting date. /s/ Amy Rabourn, by Power of Attorney 2026-04-22