X0202 4/A 2005-03-29 2005-03-31 0 0001288379 NEW RIVER PHARMACEUTICALS INC NRPH 0001091823 KIRK RANDAL J 1881 GROVE AVENUE RADFORD VA 24141 1 1 1 0 Chairman, President and CEO 0001299374 RJK, L.L.C. 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 0001235331 NEW RIVER MANAGEMENT II, LP 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 Stock Appreciation Right 12 2005-03-29 4 A 0 639000 0 A 2015-03-28 Common Stock 639000 639000 D All of these SARs are payable in cash. Adjusted for a 2-for-1 stock split effective January 13, 2006. Vests on the third anniversary of the date of grant, but at all times the exercise of SARs payable in cash will be subject to the satisfaction by the Issuer of a liquidity formula as a condition to exercise of the SARs. The vesting of these SARs will accelerate in the event of a change in control of the Issuer. /s/ Randal J. Kirk 2006-01-23 /s/ Randal J. Kirk, Manager of RJK, L.L.C. 2006-01-23 /s/ Randal J. Kirk, Senior Managing Director, Third Security, LLC, which is the Manager of Third Security Capital Partners, LLC, which is the General Partner of New River Management II, LP 2006-01-23