X0202 4 2006-01-19 0 0001288379 NEW RIVER PHARMACEUTICALS INC NRPH 0001091823 KIRK RANDAL J 1881 GROVE AVENUE RADFORD VA 24141 1 1 1 0 Chairman, President and CEO 0001235331 NEW RIVER MANAGEMENT II, LP 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 0001299374 RJK, L.L.C. 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 Stock Appreciation Right 32.71 2006-01-19 4 A 0 319500 0 A 2006-01-18 Common Stock 319500 319500 D All of these SARs are payable in cash. Vests in three equal annual installments beginning on January 19, 2007, but at all times the exercise of such SARs will be subject to the satisfaction by the Issuer of a liquidity formula as a condition to exercise of the SARs. The vesting of these SARs will accelerate in the event of a change in control of the Issuer. /s/ Randal J. Kirk 2006-01-23 /s/ Randal J. Kirk, Randal J. Kirk, Manager of RJK, L.L.C. 2006-01-23 /s/ Randal J. Kirk, Randal J. Kirk, Senior Managing Director, Third Security, LLC, which is the Manager of Third Security Capital Partners, LLC, which is the General Partner of New River Management II, LP 2006-01-23