X0202 4 2006-04-19 0 0001288379 NEW RIVER PHARMACEUTICALS INC NRPH 0001091823 KIRK RANDAL J 1881 GROVE AVENUE RADFORD VA 24141 1 1 1 0 Chairman, President and CEO 0001235331 NEW RIVER MANAGEMENT II, LP X1 0 0 1 0 0001299374 RJK, L.L.C. X1 0 0 1 0 Common Stock 2006-04-19 4 S 0 103116 33.5000 D 2278668 D Common Stock 9350 I by Lotus Common Stock 2006-04-19 4 S 0 25148 33.5000 D 555732 I by RJK2000 Common Stock 2006-04-19 4 S 0 71948 33.5000 D 1589928 I by Kirk Trust Common Stock 2006-04-19 4 S 0 56798 33.5000 D 1255122 I by Kirkfield Common Stock 2006-04-19 4 S 0 212044 33.5000 D 4685782 I by NRMII Common Stock 2006-04-19 4 S 0 70415 33.5000 D 1556047 I by NRMIII Common Stock 2006-04-19 4 S 0 276847 33.5000 D 6117810 I by RJK Common Stock 2006-04-19 4 S 0 70684 33.5000 D 1561977 I by Staff LLC Randal J. Kirk controls each of Randal J. Kirk (2000) Limited Partnership ("RJK2000"), Lotus Capital (2000) Company Inc. ("Lotus"), Kirkfield, L.L.C. ("Kirkfield"), New River Management II, LP ("NRMII"), New River Management III, LP ("NRMIII"), RJK, L.L.C. ("RJK"), Third Security Staff 2001, LLC ("Staff LLC') and R.J. Kirk Declaration of Trust ("Kirk Trust"). Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. /s/ Randal J. Kirk 2006-04-21 /s/ Randal J. Kirk, Senior Managing Director, Third Security, LLC, which is the Manager of Third Security Capital Partners, LLC, which is the General Partner of New River Management II, LP 2006-04-21 /s/ Randal J. Kirk, Manager of RJK, L.L.C. 2006-04-21