X0202 4 2006-02-13 0 0001288379 NEW RIVER PHARMACEUTICALS INC NRPH 0001091823 KIRK RANDAL J 1881 GROVE AVENUE RADFORD VA 24141 1 1 1 0 Chairman, President and CEO 0001235331 NEW RIVER MANAGEMENT II, LP 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 0001299374 RJK, L.L.C. 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 Common Stock 9350 I By Lotus Common Stock 2006-02-13 4 S 0 3573 30.1167 D 2388671 D Common Stock 2006-02-14 4 S 0 16887 30 D 2371784 D Common Stock 2006-02-13 4 S 0 872 30.1167 D 584998 I By RJK 2000 Common Stock 2006-02-14 4 S 0 4118 30 D 580880 I By RJK 2000 Common Stock 2006-02-13 4 S 0 1968 30.1167 D 1321222 I By Kirkfield Common Stock 2006-02-14 4 S 0 9302 30 D 1311920 I By Kirkfield Common Stock 2006-02-13 4 S 0 7348 30.1167 D 4932552 I By NRMII Common Stock 2006-02-14 4 S 0 34726 30 D 4897826 I By NRMII Common Stock 2006-02-13 4 S 0 2440 30.1167 D 1637994 I By NRMIII Common Stock 2006-02-14 4 S 0 11532 30 D 1626462 I By NRMIII Common Stock 2006-02-13 4 S 0 9593 30.1167 D 6439997 I By RJK Common Stock 2006-02-14 4 S 0 45340 30 D 6394657 I By RJK Common Stock 2006-02-13 4 S 0 2449 30.1167 D 1644237 I By Staff LLC Common Stock 2006-02-14 4 S 0 11576 30 D 1632661 I By Staff LLC Common Stock 2006-02-13 4 S 0 2493 30.1167 D 1673659 I By Kirk Trust Common Stock 2006-02-14 4 S 0 11783 30 D 1661876 I By Kirk Trust Randal J. Kirk controls each of Randal J. Kirk (2000) Limited Partnership ("RJK2000"), Lotus Capital (2000) Company Inc. ("Lotus"), Kirkfield, L.L.C. ("Kirkfield"), New River Management II, LP ("NRMII"), New River Management III, LP ("NRMIII"), RJK, L.L.C.("RJK"), Third Security Staff 2001, LLC("Staff LLC") and R.J. Kirk Declaration of Trust ("Kirk Trust"). Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Adjusted for a 2-for-1 stock split effective January 13, 2006. /s/ Randal J. Kirk 2006-02-15 /s/ Randal J. Kirk, Senior Managing Director, Third Security, LLC, which is the Manager of Third Security Capital Partners, LLC, which is the General Partner of New River Management II, LP 2006-02-15 /s/ Randal J. Kirk, Manager of RJK, L.L.C. 2006-02-15