X0202 4 2005-12-14 0 0001288379 NEW RIVER PHARMACEUTICALS INC NRPH 0001091823 KIRK RANDAL J 1881 GROVE AVENUE RADFORD VA 24141 1 1 1 0 Chairman, President and CEO 0001235331 NEW RIVER MANAGEMENT II, LP 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 0001299374 RJK, L.L.C. 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 Common Stock 1196122 D Common Stock 4675 I By Lotus Common Stock 2005-12-14 4 S 0 9145 47.458 D 311936 I By RJK 2000 Common Stock 2005-12-15 4 S 0 96 49.5 D 311840 I By RJK 2000 Common Stock 2005-12-16 4 S 0 2944 48.802 D 308896 I By RJK 2000 Common Stock 2005-12-14 4 S 0 20654 47.458 D 704510 I By Kirkfield Common Stock 2005-12-15 4 S 0 217 49.5 D 704293 I By Kirkfield Common Stock 2005-12-16 4 S 0 6648 48.802 D 697645 I By Kirkfield Common Stock 2005-12-14 4 S 0 77108 47.458 D 2630184 I By NRMII Common Stock 2005-12-15 4 S 0 811 49.5 D 2629373 I By NRMII Common Stock 2005-12-16 4 S 0 24820 48.802 D 2604553 I By NRMII Common Stock 2005-12-14 4 S 0 25606 47.458 D 873427 I By NRMIII Common Stock 2005-12-15 4 S 0 269 49.5 D 873158 I By NRMIII Common Stock 2005-12-16 4 S 0 8242 48.802 D 864916 I By NRMIII Common Stock 2005-12-14 4 S 0 100674 47.458 D 3433987 I By RJK Common Stock 2005-12-15 4 S 0 1059 49.5 D 3432928 I By RJK Common Stock 2005-12-16 4 S 0 32405 48.802 D 3400523 I By RJK Common Stock 2005-12-14 4 S 0 25704 47.458 D 876757 I By Staff LLC Common Stock 2005-12-15 4 S 0 271 49.5 D 876486 I By Staff LLC Common Stock 2005-12-16 4 S 0 8273 48.802 D 868213 I By Staff LLC Common Stock 2005-12-14 4 S 0 26309 47.458 D 892750 I By Kirk Trust Common Stock 2005-12-15 4 S 0 277 49.5 D 892473 I By Kirk Trust Common Stock 2005-12-16 4 S 0 8468 48.802 D 884005 I By Kirk Trust Randal J. Kirk controls each of Randal J. Kirk (2000) Limited Partnership ("RJK 2000"), Lotus Capital (2000) Company Inc. ("Lotus"), Kirkfield, L.L.C. ("Kirkfield"), New River Management II, LP ("NRMII"), New River Management III, LP ("NRMIII"), RJK, L.L.C.("RJK"), Third Security Staff 2001, LLC("Staff LLC") and R.J. Kirk Declaration of Trust ("Kirk Trust"). Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Sold pursuant to the reporting person's Rule 10b5-1 plan. /s/ Randal J. Kirk 2005-12-16 /s/ Randal J. Kirk, Senior Managing Director, Third Security, LLC, which is the Manager of Third Security Capital Partners, LLC, which is the General Partner of New River Management II, LP 2005-12-16 /s/ Randal J. Kirk, Manager of RJK, L.L.C. 2005-12-16