X0202 4 2005-12-05 0 0001288379 NEW RIVER PHARMACEUTICALS INC NRPH 0001091823 KIRK RANDAL J 1881 GROVE AVENUE RADFORD VA 24141 1 1 1 0 Chairman, President and CEO 0001299374 RJK, L.L.C. 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 0001235331 NEW RIVER MANAGEMENT II, LP 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 Common Stock 1196122 D Common Stock 4675 I By Lotus Common Stock 2005-12-05 4 S 0 763 49.13 D 323107 I By RJK 2000 Common Stock 2005-12-06 4 S 0 904 48.87 D 322203 I By RJK 2000 Common Stock 2005-12-05 4 S 0 1724 49.13 D 729740 I By Kirkfield Common Stock 2005-12-06 4 S 0 2042 48.87 D 727698 I By Kirkfield Common Stock 2005-12-05 4 S 0 6435 49.13 D 2724379 I By NRMII Common Stock 2005-12-06 4 S 0 7624 48.87 D 2716755 I By NRMII Common Stock 2005-12-05 4 S 0 2137 49.13 D 904708 I By NRMIII Common Stock 2005-12-06 4 S 0 2532 48.87 D 902176 I By NRMIII Common Stock 2005-12-05 4 S 0 8401 49.13 D 3556970 I By RJK Common Stock 2005-12-06 4 S 0 9954 48.87 D 3547016 I By RJK Common Stock 2005-12-05 4 S 0 2145 49.13 D 908158 I By Staff LLC Common Stock 2005-12-06 4 S 0 2542 48.87 D 905616 I By Staff LLC Common Stock 2005-12-05 4 S 0 2195 49.13 D 924889 I By Kirk Trust Common Stock 2005-12-06 4 S 0 2602 48.87 D 922287 I By Kirk Trust Randal J. Kirk controls each of Randal J. Kirk (2000) Limited Partnership ("RJK2000"), Lotus Capital (2000) Company Inc. ("Lotus"), Kirkfield, L.L.C. ("Kirkfield"), New River Management II, LP ("NRMII"), New River Management III, LP ("NRMIII"), RJK, L.L.C.("RJK"), Third Security Staff 2001, LLC("Staff LLC") and R.J. Kirk Declaration of Trust ("Kirk Trust"). Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Sold pursuant to the reporting person's Rule 10b5-1 plan. /s/ Randal J. Kirk 2005-12-07 /s/ Randal J. Kirk, Manager of RJK, L.L.C. 2005-12-07 /s/ Randal J. Kirk, Senior Managing Director, Third Security, LLC, which is the Manager of Third Security Capital Partners, LLC, which is the General Partner of New River Management II, LP 2005-12-07