X0202 3 2004-08-03 0 0001288379 NEW RIVER PHARMACEUTICALS INC NRPH 0001091823 KIRK RANDAL J 1881 GROVE AVENUE RADFORD VA 24141 1 1 1 0 Chairman, President and CEO 0001299374 RJK, L.L.C. 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 0001235331 NEW RIVER MANAGEMENT II LP 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 Common Stock 1383122 D Common Stock 935000 I by Lotus Capital (2000) Limited Partnership Common Stock 734014 I by Kirkfield, L.L.C. Common Stock 2740316 I by New River Management II, LP Common Stock 910000 I by New River Management III, LP Common Stock 3577788 I by RJK, L.L.C. Common Stock 913468 I by Third Security Staff 2001 LLC Stock Option (right to buy) 3.33 2006-04-02 Common Stock 5000 D Randal J. Kirk controls each of Lotus Capital (2000) Limited Partnership, Kirkfield, L.L.C., New River Management II, LP, New River Management III, LP, RJK, L.L.C., and Third Security Staff 2001 LLC. Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. All of these options are vested and immediately exercisable. /s/ Randal J. Kirk 2004-08-03 /s/ Randal J. Kirk, Senior Managing Director, Third Security, LLC, which is the Manager of Third Security Capital Partners, LLC, which is the General Partner of New River Management II, LP 2004-08-03 /s/ Randal J. Kirk, Manager of RJK, L.L.C. 2004-08-03