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Collaboration and License Agreements - Baxalta Collaboration Agreement (Details) - Baxalta Collaboration Agreement - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
One time cash payment $ 51.2  
Research and development revenue   $ 22.0