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Collaboration and License Agreements - CSL License and Option Agreement (Details) - CSL License Agreement - USD ($)
$ in Millions
12 Months Ended
Aug. 28, 2017
Jan. 05, 2017
Dec. 31, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Non-refundable upfront payment   $ 50  
Milestone payment on collaboration agreement $ 298 $ 550  
Percentage of cost sharing arrangement under collaborative and license agreements     50.00%
Maximum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Percentage of contractual profits earned under collaborative arrangement   50.00%  
Minimum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Percentage of contractual profits earned under collaborative arrangement   30.00%