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Selected Quarterly Financial Data (Unaudited) (Tables)
 12 Months Ended
Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract]  
Schedule of selected quarterly financial data
 
Quarter Ended
(in thousands, except per share data)
March 31
 
June 30
 
September 30
 
December 31
2017
 
 
 
 
 
 
 
Product revenue
$
23,404

 
$
19,140

 
$
10,890

 
$
13,369

Research and development revenue
$
3,210

 
$
4,430

 
$
13,200

 
$
51,239

Total collaboration revenue
$
26,614

 
$
23,570

 
$
24,090

 
$
64,608

Operating (loss) income
$
(32,592
)
 
$
(38,065
)
 
$
(34,527
)
 
$
12,633

Net (loss) income
$
(31,759
)
 
$
(36,908
)
 
$
(33,188
)
 
$
13,759

Comprehensive (loss) income
$
(31,825
)
 
$
(36,933
)
 
$
(33,136
)
 
$
13,572

Net (loss) income per share:
 
 
 
 
 
 
 
  Basic
$
(0.46
)
 
$
(0.50
)
 
$
(0.44
)
 
$
0.18

  Diluted
$
(0.46
)
 
$
(0.50
)
 
$
(0.44
)
 
$
0.18

Shares used in calculating net (loss) income per share:
 
 
 
 
 
 
 
  Basic
69,711

 
73,379

 
74,611

 
74,770

  Diluted
69,711

 
73,379

 
74,611

 
75,033

 
 
 
 
 
 
 
 
2016
 
 
 
 
 
 
 
Product revenue
$
14,800

 
$
20,692

 
$
23,339

 
$
15,817

Research and development revenue
$
5,050

 
$
5,738

 
$
5,805

 
$
18,378

Total collaboration revenue
$
19,850

 
$
26,430

 
$
29,144

 
$
34,195

Operating loss
$
(24,554
)
 
$
(21,639
)
 
$
(18,182
)
 
$
(10,352
)
Net (loss) income
$
(24,012
)
 
$
(20,986
)
 
$
(17,544
)
 
$
41,539

Comprehensive (loss) income
$
(23,879
)
 
$
(20,837
)
 
$
(17,580
)
 
$
41,375

Net (loss) income per share:
 
 
 
 
 
 
 
  Basic
$
(0.35
)
 
$
(0.31
)
 
$
(0.26
)
 
$
0.60

  Diluted
$
(0.35
)
 
$
(0.31
)
 
$
(0.26
)
 
$
0.60

Shares used in calculating net (loss) income per share:
 
 
 
 
 
 
 
  Basic
68,285

 
68,532

 
68,799

 
69,003

  Diluted
68,285

 
68,532

 
68,799

 
69,362