Selected Quarterly Financial Data (Unaudited)

12 Months Ended

Dec. 31, 2017

Quarterly Financial Information Disclosure [Abstract]

Selected Quarterly Financial Data (Unaudited)



	Quarter Ended
(in thousands, except per share data)	March 31			June 30			September 30			December 31
2017
Product revenue	$	23,404		$	19,140		$	10,890		$	13,369
Research and development revenue	$	3,210		$	4,430		$	13,200		$	51,239
Total collaboration revenue	$	26,614		$	23,570		$	24,090		$	64,608
Operating (loss) income	$	(32,592	)	$	(38,065	)	$	(34,527	)	$	12,633
Net (loss) income	$	(31,759	)	$	(36,908	)	$	(33,188	)	$	13,759
Comprehensive (loss) income	$	(31,825	)	$	(36,933	)	$	(33,136	)	$	13,572
Net (loss) income per share:
Basic	$	(0.46	)	$	(0.50	)	$	(0.44	)	$	0.18
Diluted	$	(0.46	)	$	(0.50	)	$	(0.44	)	$	0.18
Shares used in calculating net (loss) income per share:
Basic	69,711			73,379			74,611			74,770
Diluted	69,711			73,379			74,611			75,033

2016
Product revenue	$	14,800		$	20,692		$	23,339		$	15,817
Research and development revenue	$	5,050		$	5,738		$	5,805		$	18,378
Total collaboration revenue	$	19,850		$	26,430		$	29,144		$	34,195
Operating loss	$	(24,554	)	$	(21,639	)	$	(18,182	)	$	(10,352	)
Net (loss) income	$	(24,012	)	$	(20,986	)	$	(17,544	)	$	41,539
Comprehensive (loss) income	$	(23,879	)	$	(20,837	)	$	(17,580	)	$	41,375
Net (loss) income per share:
Basic	$	(0.35	)	$	(0.31	)	$	(0.26	)	$	0.60
Diluted	$	(0.35	)	$	(0.31	)	$	(0.26	)	$	0.60
Shares used in calculating net (loss) income per share:
Basic	68,285			68,532			68,799			69,003
Diluted	68,285			68,532			68,799			69,362

Basic and diluted net loss per common share amounts for the quarters and full years have been calculated separately. Accordingly, quarterly amounts may not add to the annual amount because of differences in the weighted-average common shares outstanding during each period principally due to the effect of the Company issuing shares of its common stock during the year.