CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Collaboration revenues:
Product revenue	$ 74,648	$ 48,503	$ 19,963
Research and development revenue	34,971	41,147	32,287
Total collaboration revenue	109,619	89,650	52,250
Operating expenses:
Research and development	119,880	126,033	106,482
General and administrative	64,466	48,051	45,164
Total operating expenses	184,346	174,084	151,646
Operating loss	(74,727)	(84,434)	(99,396)
Other income:
Interest income	2,226	808	548
Other income	51,498	313	248
Total other income	53,724	1,121	796
Net loss	$ (21,003)	$ (83,313)	$ (98,600)
Net loss per share:
Basic and diluted (in dollars per share)	$ (0.31)	$ (1.32)	$ (1.91)
Weighted average shares outstanding:
Basic and diluted (in shares)	68,656	63,130	51,664
Comprehensive loss:
Net loss	$ (21,003)	$ (83,313)	$ (98,600)
Net unrealized holding gains (losses) on available-for-sale marketable securities	82	20	(41)
Comprehensive loss	$ (20,921)	$ (83,293)	$ (98,641)