CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Parenthetical) (Unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Non-cash share-based compensation expense			$ 14,756	$ 6,787
Research and development expense
Non-cash share-based compensation expense	$ 2,042	$ 2,122	6,426	3,031
General and administrative expense
Non-cash share-based compensation expense	$ 2,897	$ 2,435	$ 8,330	$ 3,756