CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Unaudited) - USD ($) shares in Thousands, $ in Thousands		3 Months Ended		9 Months Ended
		Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Collaboration revenues:
Product revenue		$ 23,339	$ 8,666	$ 58,831	$ 30,693
Research and development revenue		5,805	5,129	16,593	36,565
Total collaboration revenue		29,144	13,795	75,424	67,258
Operating expenses:
Research and development	[1]	31,568	31,733	93,498	88,466
General and administrative	[1]	15,758	12,459	46,301	33,678
Total operating expenses		47,326	44,192	139,799	122,144
Operating loss		(18,182)	(30,397)	(64,375)	(54,886)
Other income		638	347	1,833	737
Net loss		$ (17,544)	$ (30,050)	$ (62,542)	$ (54,149)
Basic and diluted net loss per share (in dollars per share)		$ (0.26)	$ (0.44)	$ (0.91)	$ (0.88)
Weighted average shares used in computing basic and diluted net loss per share (in shares)		68,799	68,004	68,540	61,442
Comprehensive loss:
Net loss		$ (17,544)	$ (30,050)	$ (62,542)	$ (54,149)
Net unrealized holding (losses) gains on available-for-sale marketable securities		(36)	(4)	246	32
Comprehensive loss		$ (17,580)	$ (30,054)	$ (62,296)	$ (54,117)

[1] Non-cash share-based compensation expense included in operating expenses is as follows: Research and development$2,042 $2,122 $6,426 $3,031General and administrative$2,897 $2,435 $8,330 $3,756