CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Parenthetical) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Non-cash share-based compensation expense			$ 6,787	$ 10,515
Research and development expense
Non-cash share-based compensation expense	$ 2,122	$ 1,509	3,031	4,755
General and administrative expense
Non-cash share-based compensation expense	$ 2,435	$ 1,890	$ 3,756	$ 5,760