CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Collaboration revenues:
Product revenue	$ 8,666	$ 4,714	$ 30,693	$ 15,216
Research and development revenue	5,129	4,622	36,565	15,855
Total collaboration revenue	13,795	9,336	67,258	31,071
Operating expenses:
Research and development	31,733	27,508	88,466	80,289
General and administrative	12,459	11,103	33,678	34,039
Total operating expenses	44,192	38,611	122,144	114,328
Operating loss	(30,397)	(29,275)	(54,886)	(83,257)
Other income:
Interest income	252	112	486	452
Other income	95	62	251	186
Total other income	347	174	737	638
Net loss	$ (30,050)	$ (29,101)	$ (54,149)	$ (82,619)
Basic and diluted net loss per share (in dollars per share)	$ (0.44)	$ (0.56)	$ (0.88)	$ (1.61)
Weighted average shares used in computing basic and diluted net loss per share (in shares)	68,004	51,545	61,442	51,456
Comprehensive loss:
Net loss	$ (30,050)	$ (29,101)	$ (54,149)	$ (82,619)
Net unrealized holding (losses) gains on available-for-sale marketable securities	(4)	(26)	32	(5)
Comprehensive loss	$ (30,054)	$ (29,127)	$ (54,117)	$ (82,624)