CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Collaboration revenues:
Product revenue	$ 48,503	$ 19,963	$ 16,701
Research and development revenue	41,147	32,287	18,764
Total collaboration revenue	89,650	52,250	35,465
Operating expenses:
Research and development	126,033	106,482	103,999
General and administrative	48,051	45,164	41,057
Total operating expenses	174,084	151,646	145,056
Operating loss	(84,434)	(99,396)	(109,591)
Other income:
Interest income	808	548	950
Other income	313	248	233
Total other income	1,121	796	1,183
Net loss	$ (83,313)	$ (98,600)	$ (108,408)
Net loss per share:
Basic and diluted (in dollars per share)	$ (1.32)	$ (1.91)	$ (2.13)
Weighted average shares outstanding:
Basic and diluted (in shares)	63,130	51,664	50,907
Comprehensive loss:
Net loss	$ (83,313)	$ (98,600)	$ (108,408)
Net unrealized holding gains (losses) on available-for-sale marketable securities	20	(41)	(86)
Comprehensive loss	$ (83,293)	$ (98,641)	$ (108,494)