Collaborations and License Agreements (Tables)

12 Months Ended

Dec. 31, 2015

Collaborations and License Agreements

Schedules of tables providing amounts included in the company's consolidated statements of comprehensive loss attributable to transactions arising from its collaborative arrangements

	For the Year Ended December 31, 2015 (in thousands)
	2003 Sandoz Collaboration Agreement		2006 Sandoz Collaboration Agreement		Baxalta Collaboration Agreement		Total Collaborations
Collaboration revenues:
Product revenue	$	5,063	$	43,440	$	—	$	48,503
Research and development revenue:
Milestone payments		—		20,000		—		20,000
Amortization of upfront payments and license payments		—		—		9,014		9,014
Research and development services and external costs		789		2,861		8,483		12,133
Total research and development revenue	$	789	$	22,861	$	17,497	$	41,147
Total collaboration revenues	$	5,852	$	66,301	$	17,497	$	89,650
Operating expenses:
Research and development expense(1)	$	324	$	856	$	1,851	$	3,031
General and administrative expense(1)	$	344	$	206	$	963	$	1,513
Total operating expenses	$	668	$	1,062	$	2,814	$	4,544

	For the Year Ended December 31, 2014 (in thousands)
	2003 Sandoz Collaboration Agreement		2006 Sandoz Collaboration Agreement		Baxalta Collaboration Agreement		Total Collaborations
Collaboration revenues:
Product revenue	$	19,963	$	—	$	—	$	19,963
Research and development revenue:
Milestone payments		—		—		12,000		12,000
Amortization of upfront payments and license payments		—		480		3,239		3,719
Research and development services and external costs		1,043		2,452		13,073		16,568
Total research and development revenue	$	1,043	$	2,932	$	28,312	$	32,287
Total collaboration revenues	$	21,006	$	2,932	$	28,312	$	52,250
Operating expenses:
Research and development expense(1)	$	341	$	920	$	16,637	$	17,898
General and administrative expense(1)	$	125	$	299	$	527	$	951
Total operating expenses	$	466	$	1,219	$	17,164	$	18,849

	For the Year Ended December 31, 2013 (in thousands)
	2003 Sandoz Collaboration Agreement		2006 Sandoz Collaboration Agreement		Baxalta Collaboration Agreement		Total Collaborations
Collaboration revenues:
Product revenue	$	16,701	$	—	$	—	$	16,701
Research and development revenue:
Amortization of upfront payments		—		1,128		2,851		3,979
Research and development services and external costs		3,040		715		11,030		14,785
Total research and development revenue	$	3,040	$	1,843	$	13,881	$	18,764
Total collaboration revenues	$	19,741	$	1,843	$	13,881	$	35,465
Operating expenses:
Research and development expense(1)	$	802	$	2,525	$	22,707	$	26,034
General and administrative expense(1)	$	—	$	511	$	493	$	1,004
Total operating expenses	$	802	$	3,036	$	23,200	$	27,038

(1)           The amounts represent external expenditures, including amortization of an intangible asset, and exclude salaries and benefits, share-based compensation, facilities, depreciation and laboratory supplies, as these costs are not directly charged to programs.