Selected Quarterly Financial Data (Unaudited)

12 Months Ended

Dec. 31, 2015

Selected Quarterly Financial Data (Unaudited)

Selected Quarterly Financial Data (Unaudited)

17. Selected Quarterly Financial Data (Unaudited)

	Quarter Ended
(in thousands, except per share data)	March 31			June 30			September 30			December 31
2015
Product revenue	$	2,722		$	19,305		$	8,666		$	17,810
Research and development revenue	$	5,840		$	25,595		$	5,129		$	4,583
Total collaboration revenue	$	8,562		$	44,900		$	13,795		$	22,393
Net loss	$	(21,877	)	$	(2,222	)	$	(30,050	)	$	(29,164	)
Comprehensive loss	$	(21,859	)	$	(2,204	)	$	(30,054	)	$	(29,176	)
Basic and diluted net loss per common share	$	(0.40	)	$	(0.04	)	$	(0.44	)	$	(0.43	)
Shares used in computing basic and diluted net loss per common share		54,492			61,680			68,004			68,138
2014
Product revenue	$	4,812		$	5,690		$	4,714		$	4,747
Research and development revenue	$	5,973		$	5,260		$	4,622		$	16,432
Total collaboration revenue	$	10,785		$	10,950		$	9,336		$	21,179
Net loss	$	(27,362	)	$	(26,156	)	$	(29,101	)	$	(15,981	)
Comprehensive loss	$	(27,378	)	$	(26,119	)	$	(29,127	)	$	(16,017	)
Basic and diluted net loss per common share	$	(0.53	)	$	(0.51	)	$	(0.56	)	$	(0.31	)
Shares used in computing basic and diluted net loss per common share		51,356			51,466			51,545			52,255

        Basic and diluted net loss per common share amounts for the quarters and full years have been calculated separately. Accordingly, quarterly amounts may not add to the annual amount because of differences in the weighted-average common shares outstanding during each period principally due to the effect of the Company issuing shares of its common stock during the year.