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Related-Party Transactions (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2011
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2011
Related Party Transaction [Line Items]                          
Research and Development Expense   $ 8,188 $ 5,985 $ 6,788 $ 6,531 $ 6,386 $ 6,582 $ 6,724 $ 6,617 $ 27,492,185 $ 26,309,475 $ 41,649,389  
Operating Leases, Rent Expense, Net, Total                   743,323 736,249 866,768  
Purdue Research Foundation                          
Related Party Transaction [Line Items]                          
Research and Development Expense                   1,069,000 1,000,000 1,000,000  
Operating Leases, Rent Expense, Net, Total                   597,000 588,000 592,000  
Accounts Payable and Other Accrued Liabilities   $ 182,000               182,000      
On Target                          
Related Party Transaction [Line Items]                          
Proceeds from License Fees Received $ 191,000                        
License and Maintenance Revenue                   20,000 20,000 20,000  
On Target | Research and Development Expense                          
Related Party Transaction [Line Items]                          
Reimbursement Revenue                   $ 14,397 $ 21,044 $ 50,614  
On Target | Patents [Member]                          
Related Party Transaction [Line Items]                          
Reimbursement Revenue                         $ 50,000