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Income Taxes - Effective rate reconciliation (Details)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income Tax Disclosure [Abstract]      
Income tax computed at federal statutory tax rate 34.00% 34.00% 34.00%
State taxes, net of federal benefit 3.30% 3.20% 6.30%
State taxes rate change, net of federal benefit 0.00% 0.00% 30.40%
International operations (0.70%) (4.80%) 6.60%
Research and development credits 4.00% 3.80% (22.60%)
Orphan drug credits 0.60% 0.90% (57.40%)
Equity compensation (3.70%) (2.00%) 16.60%
Other 0.00% 0.00% (2.10%)
Change in valuation allowance (37.50%) (35.10%) (11.80%)
Total 0.00% 0.00% 0.00%