Restructuring Costs (Tables)

12 Months Ended

Dec. 31, 2016

Restructuring Costs [Abstract]

Schedule of restructuring and related costs

The following table summarizes the restructuring accruals for the years ended December 31, 2014, 2015 and 2016:

	Employee and		PROCEED
	Contract		Trial
	Termination		Termination
	Accrual		Accrual		Total
Balance, January 1, 2014	$	—	$	—	$	—
Charges for the year ended December 31, 2014		1,300,000		4,100,000		5,400,000
Amounts paid in the year ended December 31, 2014		(1,300,000)		(2,800,000)		(4,100,000)
Balance, December 31, 2014	$	—	$	1,300,000	$	1,300,000
Balance, January 1, 2015		—		1,300,000		1,300,000
Revised estimates in the year ended December 31, 2015		—		134,000		134,000
Amounts paid in the year ended December 31, 2015		—		(1,387,400)		(1,387,400)
Balance, December 31, 2015	$	—	$	46,600	$	46,600
Balance, January 1, 2016	$	—	$	46,600	$	46,600
Revised estimates in the year ended December 31, 2016		—		(15,800)		(15,800)
Amounts paid in the year ended December 31, 2016		—		(30,800)		(30,800)
Balance, December 31, 2016	$	—	$	—	$	—