Restructuring Costs (Details) - Proceed Trial Termination - USD ($)	12 Months Ended
	Dec. 31, 2014	Sep. 30, 2016	Jun. 30, 2016	Dec. 31, 2015
Restructuring Costs
Restructuring Charges, Total	$ 4,100,000
Clinical trial reserve balance		$ 17,800	$ 23,600	$ 46,600