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Selected Quarterly Financial Data (unaudited) (Tables)
 12 Months Ended
Dec. 31, 2014
Quarterly Financial Information Disclosure [Abstract]  
Condensed Income Statement [Table Text Block]

The following table summarizes the unaudited statements of operations for each quarter of 2014 and 2013 (in thousands except share and per share amounts):
 
 
 
Quarters Ended
March 31
June 30
September 30
December 31
2014
Revenue
$
17,269
$
49,168
$
3,904
$
12
Operating Expenses:
Research and development
12,987
18,990
5,675
3,998
General and administrative
7,501
7,968
4,007
4,201
Income (loss) from operations
(3,219
)
22,210
(5,778
)
(8,187
)
Interest, net
85
168
161
164
Other
(7
)
(22
)
(58
)
(58
)
Net income (loss)
$
(3,141
)
$
22,356
$
(5,675
)
$
(8,081
)
Basic net income (loss) per share(1)
$
(0.09
)
$
0.54
$
(0.14
)
$
(0.19
)
Diluted net income (loss) per share(1)
$
(0.09
)
$
0.52
$
(0.14
)
$
(0.19
)
Weighted average common shares outstanding – basic
36,193,942
41,398,251
41,564,840
41,736,930
Weighted average common shares outstanding – diluted
36,193,942
43,196,754
41,564,840
41,736,930
 
 
 
Quarters Ended
March 31
June 30
September 30
December 31
2013
Revenue
$
14,514
$
16,483
$
16,600
$
17,274
Operating Expenses:
Research and development
12,259
18,607
13,501
13,533
General and administrative
6,256
6,211
6,143
6,704
Loss from operations
(4,001
)
(8,335
)
(3,044
)
(2,963
)
Interest, net
139
126
111
89
Other
—
(18
)
(108
)
(28
)
Net loss
$
(3,862
)
$
(8,227
)
$
(3,041
)
$
(2,902
)
Basic and diluted net loss per share(1)
$
(0.11
)
$
(0.23
)
$
(0.08
)
$
(0.08
)
Weighted average common shares
outstanding – basic and diluted(2)
35,930,265
35,991,402
36,077,440
36,146,061
 
(1)
Per common share amounts for the quarters and full years have been calculated separately. Accordingly, the sum of quarterly amounts may not equal the annual amount because of differences in the weighted average common shares outstanding during each period, principally due to the effect of share issuances by the Company during the year.
(2)
Diluted weighted average common shares outstanding are identical to basic weighted average common shares outstanding and diluted net loss per share is identical to basic net loss per share for all quarters of 2013 because common share equivalents are excluded from the calculations of diluted weighted average common shares outstanding for those quarters, as their effect is anti-dilutive.