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Restructuring Costs (Tables)
12 Months Ended
Dec. 31, 2014
Restructuring Costs [Abstract]  
Restructuring and Related Costs [Table Text Block]
The following table summarizes the restructuring accruals for the year ended December 31, 2014:
 
 
Employee and
Contract
Termination
Accrual
PROCEED
Trial
Termination
Accrual
Total
Balance, January 1, 2014
$
—
$
—
$
—
Charges for the year ended December 31, 2014
1,300,000
4,100,000
5,400,000
Amounts paid in the year ended December 31, 2014
(1,300,000
)
(2,800,000
)
(4,100,000
)
Balance, December 31, 2014
$
—
$
1,300,000
$
1,300,000