X0306 4 2017-06-15 0 0001501756 Adverum Biotechnologies, Inc. ADVM 0001233539 PATTERSON LEONE D C/O ADVERUM BIOTECHNOLOGIES, INC. 1035 O'BRIEN DRIVE MENLO PARK CA 94025 1 1 0 0 CEO, President and Director Common Stock 2017-06-15 4 F 0 9395 2.70 D 170605 D Common Stock 2018-02-09 4 F 0 8208 7.05 D 162397 D Common Stock 2018-06-15 4 F 0 8645 5.55 D 242248 D Common Stock 2019-02-09 4 F 0 8176 3.33 D 234072 D Common Stock 2019-06-15 4 F 0 8570 10.82 D 225502 D Common Stock 2019-06-15 4 F 0 35282 10.82 D 190220 D Constitutes shares withheld to cover withholding tax obligations. Does not tie to prior filings as the prior filings did not take into account this transaction. The Form 4 for the latest transaction by the undersigned will be amended to reflect the then current ownership following the transaction reported on that latest filing. Leone Patterson by /s/ Thomas Leung, Attorney-in-Fact. 2020-02-10