X0306 4 2019-12-23 0 0001501756 Adverum Biotechnologies, Inc. ADVM 0001233539 PATTERSON LEONE D C/O ADVERUM BIOTECHNOLOGIES, INC. 1035 O'BRIEN DRIVE MENLO PARK CA 94025 1 1 0 0 CEO, President and Director Common Stock 2019-12-23 4 S 0 40000 10.72 D 228496 D This transaction was pursuant to a 10b5-1 Plan. Represents weighted average sales price. The shares were sold at prices ranging from $10.30 to $11.055. The Reporting Person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. /s/ Leone Patterson 2019-12-26