X0306 4 2018-06-15 0 0001501756 Adverum Biotechnologies, Inc. ADVM 0001233539 PATTERSON LEONE D C/O ADVERUM BIOTECHNOLOGIES, INC. 1035 O'BRIEN DRIVE MENLO PARK CA 94025 0 1 0 0 SVP, CFO, Interim Pres and CEO Common Stock 2018-06-15 4 A 0 88496 0.00 A 268496 D Represents Restricted Stock Units ("RSUs"). The Reporting Person is entitled to receive one (1) share of Common Stock of the Issuer for each one (1) RSU upon the vesting thereof. Such RSUs vest with respect to 100% of the shares on June 15, 2019, subject to the Reporting Person's continued service with the Issuer on the applicable vesting date. /s/ Leone Patterson 2018-06-18