<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: TANG CAPITAL MANAGEMENT LLC -->
          <cik>0001232621</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>American Depositary Shares, each representing one ordinary share, nominal value GBP 0.002 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>10/17/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001671927</issuerCik>
        <issuerName>Immunocore Holdings plc</issuerName>
        <issuerCusip>45258D105</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>90 Park Drive</com:street1>
          <com:street2>Milton Park, Abingdon</com:street2>
          <com:city>Oxfordshire</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>OX14 4RY</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>TANG CAPITAL MANAGEMENT, LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2605608.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2605608.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2605608.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.2</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>Tang Capital Management, LLC ("TCM") beneficially owns 2,605,608 American Depository Shares ("ADSs") which each represent one Ordinary Share. The percentages used herein are based on 50,387,068 Ordinary Shares outstanding as of July 31, 2025, as set forth in the Quarterly Report filed on Form 10-Q that was filed with the Securities and Exchange Commission on August 7, 2025. TCM shares voting and dispositive power over such shares with Tang Capital Partners, LP ("TCP"), Tang Capital Partners International, LP ("TCPI") and Kevin Tang.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>KEVIN TANG</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2605608.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2605608.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2605608.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.2</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Kevin Tang beneficially owns 2,605,608 ADSs which each represent one Ordinary Share. Kevin Tang shares voting and dispositive power over such shares with TCP, TCPI and TCM.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>TANG CAPITAL PARTNERS, LP</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>1587903.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1587903.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1587903.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>3.2</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>TCP beneficially owns 1,587,903 ADSs which each represent one Ordinary Share. TCP shares voting and dispositive power over such shares with TCM and Kevin Tang.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>TANG CAPITAL PARTNERS INTERNATIONAL, LP</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>1017705.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1017705.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1017705.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.0</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>TCPI beneficially owns 1,017,705 ADSs which each represent one Ordinary Share. TCPI shares voting and dispositive power over such shares with TCM and Kevin Tang.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>TANG CAPITAL PARTNERS III, INC</reportingPersonName>
      <citizenshipOrOrganization>NV</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0.0</classPercent>
      <typeOfReportingPerson>CO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>TANG CAPITAL PARTNERS IV, INC</reportingPersonName>
      <citizenshipOrOrganization>NV</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0.0</classPercent>
      <typeOfReportingPerson>CO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Immunocore Holdings plc</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>90 Park Drive, Milton Park, Abingdon, Oxfordshire, United Kingdom, OX14 4RY</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This Statement on Schedule 13G (this "Statement") is filed by TCM, the general partner of TCP and TCPI; Kevin Tang, the manager of TCM and Chief Executive Officer of Tang Capital Partners III, Inc. ("TCP III") and Tang Capital Partners IV, Inc. ("TCP IV"); TCP; TCPI; TCP III; and TCP IV.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address of TCM, Kevin Tang, TCP and TCPI is 4747 Executive Drive, Suite 210, San Diego, CA 92121. The address of TCP III and TCP IV is 400 S. 4th Street, 3rd Floor, Las Vegas, NV 89101.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>TCM is a Delaware limited liability company. Mr. Tang is a United States citizen. TCP and TCPI are Delaware limited partnerships. TCP III and TCP IV are Nevada corporations that are indirectly wholly owned by TCP.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>2,605,608</amountBeneficiallyOwned>
        <classPercent>5.2</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>0 shares</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>2,605,608 shares</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>0 shares</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>2,605,608 shares</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>TANG CAPITAL MANAGEMENT, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Tang</signature>
        <title>Manager</title>
        <date>10/24/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>KEVIN TANG</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Tang</signature>
        <title>Self</title>
        <date>10/24/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>TANG CAPITAL PARTNERS, LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Tang</signature>
        <title>Manager, Tang Capital Management, LLC, General Partner</title>
        <date>10/24/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>TANG CAPITAL PARTNERS INTERNATIONAL, LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Tang</signature>
        <title>Manager, Tang Capital Management, LLC, General Partner</title>
        <date>10/24/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>TANG CAPITAL PARTNERS III, INC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Tang</signature>
        <title>Chief Executive Officer</title>
        <date>10/24/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>TANG CAPITAL PARTNERS IV, INC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Tang</signature>
        <title>Chief Executive Officer</title>
        <date>10/24/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
