SCHEDULE 13G/A 0001232621 XXXXXXXX LIVE 4 Common Stock, par value $0.00001 per share 03/31/2025 0001501989 CytomX Therapeutics, Inc. 23284F105 151 Oyster Point Boulevard Suite 400 South San Francisco CA 94080 Rule 13d-1(c) TANG CAPITAL MANAGEMENT, LLC DE 0.00 6717825.00 0.00 6717825.00 6717825.00 N 8.4 OO Tang Capital Management, LLC ("TCM") shares voting and dispositive power over such shares with Tang Capital Partners, LP ("TCP"), Tang Capital Partners International, LP ("TCPI") and Kevin Tang. The percentages used herein are based on 80,099,889 shares of Common Stock outstanding as of February 28, 2025, as set forth in the Issuer's Annual Report filed on Form 10-K that was filed with the Securities and Exchange Commission on March 6, 2025. KEVIN TANG X1 0.00 6717825.00 0.00 6717825.00 6717825.00 N 8.4 IN Kevin Tang shares voting and dispositive power over such shares with TCP, TCPI and TCM. TANG CAPITAL PARTNERS, LP DE 0.00 4964773.00 0.00 4964773.00 4964773.00 N 6.2 PN TCP shares voting and dispositive power over such shares with TCM and Kevin Tang. TANG CAPITAL PARTNERS INTERNATIONAL, LP DE 0.00 1753052.00 0.00 1753052.00 1753052.00 N 2.2 PN TCPI shares voting and dispositive power over such shares with TCM and Kevin Tang. TANG CAPITAL PARTNERS III, INC NV 0.00 0.00 0.00 0.00 0.00 N 0.0 CO TANG CAPITAL PARTNERS IV, INC NV 0.00 0.00 0.00 0.00 0.00 N 0.0 CO CytomX Therapeutics, Inc. 151 Oyster Point Boulevard, Suite 400, South San Francisco, CA, 94080 This Statement on Schedule 13G (this "Statement") is filed by TCM, the general partner of TCP and TCPI; Kevin Tang, the manager of TCM and Chief Executive Officer of Tang Capital Partners III, Inc. ("TCP III") and Tang Capital Partners IV, Inc. ("TCP IV"); TCP; TCPI; TCP III; and TCP IV. The address of TCM, Kevin Tang, TCP and TCPI is 4747 Executive Drive, Suite 210, San Diego, CA 92121. The address of TCP III and TCP IV is 400 S. 4th Street, 3rd Floor, Las Vegas, NV 89101. TCM is a Delaware limited liability company. Mr. Tang is a United States citizen. TCP and TCPI are Delaware limited partnerships. TCP III and TCP IV are Nevada corporations that are indirectly wholly owned by TCP. Y 6,717,825 8.4% 0 shares 6,717,825 shares 0 shares 6,717,825 shares Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. TANG CAPITAL MANAGEMENT, LLC /s/ Kevin Tang 05/15/2025 KEVIN TANG /s/ Kevin Tang 05/15/2025 TANG CAPITAL PARTNERS, LP /s/ Kevin Tang 05/15/2025 TANG CAPITAL PARTNERS INTERNATIONAL, LP /s/ Kevin Tang 05/15/2025 TANG CAPITAL PARTNERS III, INC /s/ Kevin Tang 05/15/2025 TANG CAPITAL PARTNERS IV, INC /s/ Kevin Tang 05/15/2025