SCHEDULE 13G/A 0001214659-24-016878 0001232621 XXXXXXXX LIVE 1 Common Stock, par value $0.001 per share 12/31/2024 0001808865 ITeos Therapeutics, Inc. 46565G104 321 Arsenal Street Watertown MA 02472 Rule 13d-1(c) TANG CAPITAL MANAGEMENT, LLC DE 0.00 221716.00 0.00 221716.00 221716.00 N 0.6 OO Tang Capital Management, LLC ("TCM") shares voting and dispositive power over such shares with Tang Capital Partners, LP ("TCP") and Kevin Tang. The percentages used herein are based on 36,533,918 shares of Common Stock outstanding as of November 7, 2024, as set forth in the Issuer's Quarterly Report filed on Form 10-Q that was filed with the Securities and Exchange Commission on November 12, 2024. KEVIN TANG X1 0.00 221716.00 0.00 221716.00 221716.00 N 0.6 IN Kevin Tang shares voting and dispositive power over such shares with TCP and TCM. TANG CAPITAL PARTNERS, LP DE 0.00 221716.00 0.00 221716.00 221716.00 N 0.6 PN TCP shares voting and dispositive power over such shares with TCM and Kevin Tang. TANG CAPITAL PARTNERS III, INC NV 0.00 0.00 0.00 0.00 0.00 N 0.0 CO TANG CAPITAL PARTNERS IV, INC NV 0.00 0.00 0.00 0.00 0.00 N 0.0 CO ITeos Therapeutics, Inc. 321 Arsenal Street, Watertown, MA 02472 This Statement on Schedule 13G (this "Statement") is filed by TCM, the general partner of TCP; Kevin Tang, the manager of TCM and Chief Executive Officer of Tang Capital Partners III, Inc. ("TCP III") and Tang Capital Partners IV, Inc. ("TCP IV"); TCP; TCP III; and TCP IV. The address of TCM, Kevin Tang and TCP is 4747 Executive Drive, Suite 210, San Diego, CA 92121. The address of TCP III and TCP IV is 5955 Edmond Street, Las Vegas, NV 89118. TCM is a Delaware limited liability company. Mr. Tang is a United States citizen. TCP is a Delaware limited partnership. TCP III and TCP IV are Nevada corporations that are indirectly wholly owned by TCP. Y 221,716 0.6 0 shares 221,716 shares 0 shares 221,716 shares N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. TANG CAPITAL MANAGEMENT, LLC /s/ Kevin Tang 02/14/2025 KEVIN TANG /s/ Kevin Tang 02/14/2025 TANG CAPITAL PARTNERS, LP /s/ Kevin Tang 02/14/2025 TANG CAPITAL PARTNERS III, INC /s/ Kevin Tang 02/14/2025 TANG CAPITAL PARTNERS IV, INC /s/ Kevin Tang 02/14/2025