The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102   666,000 100,000 SH   OTR 1 0 100,000 0
ACADIA PHARMACEUTICALS INC COM 004225108   2,084,000 100,000 SH   OTR 1 0 100,000 0
ACELRX PHARMACEUTICALS INC COM NEW 00444T209   113,100 195,000 SH   OTR 1 0 195,000 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   4,030,224 5,166,954 SH   OTR 1 0 5,166,954 0
ADICET BIO INC COM 007002108   1,680,102 1,226,352 SH   OTR 1 0 1,226,352 0
ADMA BIOLOGICS INC COM 000899104   4,868,800 1,360,000 SH   OTR 1 0 1,360,000 0
ALIGOS THERAPEUTICS INC COM 01626L105   2,486,799 3,329,048 SH   OTR 1 0 3,329,048 0
ALTIMMUNE INC COM NEW 02155H200   7,150,000 2,750,000 SH   OTR 1 0 2,750,000 0
AMARIN CORP PLC SPONS ADR NEW 023111206   5,393,516 5,862,517 SH   OTR 1 0 5,862,517 0
ANAPTYSBIO INC COM 032724106   35,032,938 1,950,609 SH   OTR 1 0 1,950,609 0
ARS PHARMACEUTICALS INC COM 82835W108   1,547,770 409,463 SH   OTR 1 0 409,463 0
ARVINAS INC COM 04335A105   1,571,200 80,000 SH   OTR 1 0 80,000 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   936,400 10,000 SH   OTR 1 0 10,000 0
ASLAN PHARMACEUTICALS LTD SPON ADS NEW 04522R200   3,574,918 1,901,552 SH   OTR 1 0 1,901,552 0
ASTRAZENECA PLC SPONSORED ADR 046353108   11,512,400 170,000 SH   OTR 1 0 170,000 0
ATEA PHARMACEUTICALS INC COM 04683R106   10,800,000 3,600,000 SH   OTR 1 0 3,600,000 0
ATHIRA PHARMA INC COM 04746L104   712,484 352,715 SH   OTR 1 0 352,715 0
ATYR PHARMA INC COM NEW 002120202   744,392 471,134 SH   OTR 1 0 471,134 0
AURINIA PHARMACEUTICALS INC COM 05156V102   5,827,500 750,000 SH   OTR 1 0 750,000 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104   10,300,000 1,000,000 SH   OTR 1 0 1,000,000 0
AVROBIO INC COM 05455M100   5,409,536 3,512,686 SH   OTR 1 0 3,512,686 0
AXSOME THERAPEUTICS INC COM 05464T104   22,364,800 320,000 SH   OTR 1 0 320,000 0
BANK HAWAII CORP COM 062540109   1,490,700 30,000 SH   OTR 1 0 30,000 0
BEIGENE LTD SPONSORED ADR 07725L102   15,288,950 85,000 SH   OTR 1 0 85,000 0
BIO RAD LABS INC CL A 090572207   8,602,800 24,000 SH   OTR 1 0 24,000 0
BIOATLA INC COM 09077B104   6,423,268 3,778,393 SH   OTR 1 0 3,778,393 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   12,744,000 1,800,000 SH   OTR 1 0 1,800,000 0
BIOHAVEN LTD COM G1110E107   3,641,400 140,000 SH   OTR 1 0 140,000 0
BIONOMICS LIMITED ADS 09063M205   1,890,000 700,000 SH   OTR 1 0 700,000 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   1,148,000 400,000 SH   OTR 1 0 400,000 0
BLUEBIRD BIO INC COM 09609G100   13,019,794 4,282,827 SH   OTR 1 0 4,282,827 0
BOLT BIOTHERAPEUTICS INC COM 097702104   3,699,322 3,557,040 SH   OTR 1 0 3,557,040 0
CITIGROUP INC COM NEW 172967424   4,113,000 100,000 SH   OTR 1 0 100,000 0
COHERUS BIOSCIENCES INC COM 19249H103   1,496,000 400,000 SH   OTR 1 0 400,000 0
CYMABAY THERAPEUTICS INC COM 23257D103   2,982,000 200,000 SH   OTR 1 0 200,000 0
CYTOMX THERAPEUTICS INC COM 23284F105   8,320,500 6,450,000 SH   OTR 1 0 6,450,000 0
CULLINAN ONCOLOGY INC COM 230031106   5,621,299 621,138 SH   OTR 1 0 621,138 0
CVB FINL CORP COM 126600105   3,314,000 200,000 SH   OTR 1 0 200,000 0
DESIGN THERAPEUTICS INC COM 25056L103   3,186,000 1,350,000 SH   OTR 1 0 1,350,000 0
DIANTHUS THERAPEUTICS INC COM 252828108   8,087,664 591,636 SH   OTR 1 0 591,636 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201   4,431,000 300,000 SH   OTR 1 0 300,000 0
EAGLE PHARMACEUTICALS INC COM 269796108   1,874,375 118,857 SH   OTR 1 0 118,857 0
EDITAS MEDICINE INC COM 28106W103   1,560,000 200,000 SH   OTR 1 0 200,000 0
ELEVATION ONCOLOGY INC COM 28623U101   2,650,400 4,000,000 SH   OTR 1 0 4,000,000 0
ELI LILLY & CO COM 532457108   16,113,900 30,000 SH   OTR 1 0 30,000 0
ENZO BIOCHEM INC COM 294100102   3,080,000 2,200,000 SH   OTR 1 0 2,200,000 0
EQRX INC COM 26886C107   22,391,164 10,086,110 SH   OTR 1 0 10,086,110 0
EQUILLIUM INC COM 29446K106   296,000 400,000 SH   OTR 1 0 400,000 0
EQUITY COMWLTH COM SH BEN INT 294628102   5,511,000 300,000 SH   OTR 1 0 300,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105   1,813,000 1,850,000 SH   OTR 1 0 1,850,000 0
EVOLUS INC COM 30052C107   28,310,227 3,097,399 SH   OTR 1 0 3,097,399 0
FATE THERAPEUTICS INC COM 31189P102   1,484,000 700,000 SH   OTR 1 0 700,000 0
GALAPAGOS NV SPON ADR 36315X101   3,097,408 89,650 SH   OTR 1 0 89,650 0
GENEDX HOLDINGS CORP COM CL A 81663L200   231,636 63,636 SH   OTR 1 0 63,636 0
GENFIT S A ADS 372279109   3,402,880 1,040,636 SH   OTR 1 0 1,040,636 0
GOSSAMER BIO INC COM 38341P102   698,386 838,600 SH   OTR 1 0 838,600 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   458,171 159,087 SH   OTR 1 0 159,087 0
GRAPHITE BIO INC COM 38870X104   5,001,232 2,016,626 SH   OTR 1 0 2,016,626 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   8,887,224 271,200 SH   OTR 1 0 271,200 0
HERON THERAPEUTICS INC COM 427746102   1,905,500 1,850,000 SH   OTR 1 0 1,850,000 0
IMMUNOCORE HLDGS PLC ADS 45258D105   21,050,640 405,600 SH   OTR 1 0 405,600 0
IMMUNOGEN INC COM 45253H101   23,805,000 1,500,000 SH   OTR 1 0 1,500,000 0
INFLARX NV COM N44821101   8,416,572 2,824,353 SH   OTR 1 0 2,824,353 0
INSMED INC COM PAR $.01 457669307   4,196,626 166,203 SH   OTR 1 0 166,203 0
INSPIRATO INCORPORATED COM CL A 45791E107   516,590 875,577 SH   OTR 1 0 875,577 0
INTELLIA THERAPEUTICS INC COM 45826J105   12,572,112 397,600 SH   OTR 1 0 397,600 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   15,627,000 300,000 SH   OTR 1 0 300,000 0
INVIVYD INC COM 00534A102   623,111 366,536 SH   OTR 1 0 366,536 0
IONIS PHARMACEUTICALS INC COM 462222100   9,072,000 200,000 SH   OTR 1 0 200,000 0
JOURNEY MED CORP COM 48115J109   1,578,514 576,100 SH   OTR 1 0 576,100 0
KALVISTA PHARMACEUTICALS INC COM 483497103   33,130,522 3,440,345 SH   OTR 1 0 3,440,345 0
KARUNA THERAPEUTICS INC COM 48576A100   1,690,900 10,000 SH   OTR 1 0 10,000 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101   10,422,000 600,000 SH   OTR 1 0 600,000 0
LIANBIO SPONSORED ADS 53000N108   2,682,000 1,800,000 SH   OTR 1 0 1,800,000 0
MEI PHARMA INC COM 55279B301   2,285,849 326,084 SH   OTR 1 0 326,084 0
MIRATI THERAPEUTICS INC COM 60468T105   7,840,800 180,000 SH   OTR 1 0 180,000 0
MIRUM PHARMACEUTICALS INC COM 604749101   35,932,581 1,137,107 SH   OTR 1 0 1,137,107 0
MODERNA INC COM 60770K107   7,922,343 76,700 SH   OTR 1 0 76,700 0
MOLECULAR PARTNERS AG ADS 60853G106   414,000 100,000 SH   OTR 1 0 100,000 0
NEKTAR THERAPEUTICS COM 640268108   2,346,426 3,939,600 SH   OTR 1 0 3,939,600 0
NEURONETICS INC COM 64131A105   270,000 200,000 SH   OTR 1 0 200,000 0
NEXTCURE INC COM 65343E108   516,000 400,000 SH   OTR 1 0 400,000 0
NEW YORK CMNTY BANCORP INC COM 649445103   18,218,844 1,606,600 SH   OTR 1 0 1,606,600 0
NKARTA INC COM 65487U108   1,534,057 1,103,638 SH   OTR 1 0 1,103,638 0
NOVOCURE LTD ORD SHS G6674U108   7,947,415 492,100 SH   OTR 1 0 492,100 0
PASSAGE BIO INC COM 702712100   263,200 400,000 SH   OTR 1 0 400,000 0
PDS BIOTECHNOLOGY CORP COM 70465T107   2,020,000 400,000 SH   OTR 1 0 400,000 0
QUINCE THERAPEUTICS INC COM 22053A107   3,918,732 3,498,868 SH   OTR 1 0 3,498,868 0
RAIN ONCOLOGY INC COM 75082Q105   3,223,426 3,740,341 SH   OTR 1 0 3,740,341 0
ROCKET PHARMACEUTICALS INC COM 77313F106   3,073,500 150,000 SH   OTR 1 0 150,000 0
SELECTA BIOSCIENCES INC COM 816212104   424,000 400,000 SH   OTR 1 0 400,000 0
SERVISFIRST BANCSHARES INC COM 81768T108   1,565,100 30,000 SH   OTR 1 0 30,000 0
STELLAR BANCORP INC COM 858927106   426,400 20,000 SH   OTR 1 0 20,000 0
TANGO THERAPEUTICS INC COM 87583X109   2,252,000 200,000 SH   OTR 1 0 200,000 0
TARSUS PHARMACEUTICALS INC COM 87650L103   38,038,213 2,140,586 SH   OTR 1 0 2,140,586 0
TG THERAPEUTICS INC COM 88322Q108   836,000 100,000 SH   OTR 1 0 100,000 0
THIRD HARMONIC BIO INC COM 88427A107   11,502,000 1,800,000 SH   OTR 1 0 1,800,000 0
TRANSCODE THERAPEUTICS INC COM NEW 89357L204   42,232 84,010 SH   OTR 1 0 84,010 0
UNIQURE NV SHS N90064101   6,279,218 935,800 SH   OTR 1 0 935,800 0
US BANCORP DEL COM NEW 902973304   3,306,000 100,000 SH   OTR 1 0 100,000 0
VAXCYTE INC COM 92243G108   15,294,000 300,000 SH   OTR 1 0 300,000 0
VERASTEM INC COM NEW 92337C203   7,248,009 891,514 SH   OTR 1 0 891,514 0
VERITEX HLDGS INC COM 923451108   3,769,500 210,000 SH   OTR 1 0 210,000 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   10,264,378 669,125 SH   OTR 1 0 669,125 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103   279,000 150,000 SH   OTR 1 0 150,000 0
ZYMEWORKS INC COM 98985Y108   6,974,000 1,100,000 SH   OTR 1 0 1,100,000 0