X0306 4 2018-09-12 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001178579 TANG KEVIN C 4747 EXECUTIVE DRIVE SUITE 510 SAN DIEGO CA 92121 1 0 1 0 0001232621 TANG CAPITAL MANAGEMENT LLC 4747 EXECUTIVE DRIVE, SUITE 510 SAN DIEGO CA 92121 0 0 1 0 0001191935 TANG CAPITAL PARTNERS LP 4747 EXECUTIVE DRIVE, SUITE 510 SAN DIEGO CA 92121 0 0 1 0 Common Stock 2018-09-12 4 S 0 2695000 35.75 D 5830215 I By LP Common Stock 14347 I As Trustee Common Stock 6941 D The Reporting Person's sale of common stock reported herein may be deemed to be matchable under Section 16(b) of the Securities Exchange Act of 1934, as amended, to the extent of 192,308 shares of common stock purchased by the Reporting Person on March 29, 2018. The Reporting Person has sent to the Issuer the full amount of the disgorgeable profit arising from the sale reported herein. The securities are held by Tang Capital Partners, LP. Kevin C. Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. The securities are held by Kevin C. Tang as custodian for his minor children, as Trustee of the Kevin C. Tang Family Trust, and as Trustee of the Tang Advisors, LLC Profit Sharing Plan. 2,147 of these securities are held by Kevin C. Tang's IRA. /s/ Kevin C. Tang 2018-09-12 /s/ Kevin C. Tang, Managing Member 2018-09-12 /s/ Kevin C. Tang, as Managing Member of Tang Capital Management, LLC, General Partner 2018-09-12