X0306 4 2017-01-19 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001178579 TANG KEVIN C 4747 EXECUTIVE DRIVE SUITE 510 SAN DIEGO CA 92121 1 0 1 0 0001232621 TANG CAPITAL MANAGEMENT LLC 4747 EXECUTIVE DRIVE, SUITE 510 SAN DIEGO CA 92121 0 0 1 0 0001191935 TANG CAPITAL PARTNERS LP 4747 EXECUTIVE DRIVE, SUITE 510 SAN DIEGO CA 92121 0 0 1 0 Common Stock 2017-01-19 4 P 0 2459016 12.20 A 8332907 I By LP Common Stock 14347 I As Trustee Common Stock 6941 D The securities are held by Tang Capital Partners, LP and Tang (APPA) Holdings, LLC. Kevin C. Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. Tang Capital Partners, LP is the sole manager of Tang (APPA) Holdings, LLC. Mr. Tang disclaims beneficial ownership of the securities except to the extent of his pecuniary interest therein. The securities are held by Kevin C. Tang as custodian for his minor children, as Trustee of the Kevin C. Tang Family Trust, and as Trustee of the Tang Advisors, LLC Profit Sharing Plan. 2,147 of these securities are held by Kevin C. Tang's IRA. /s/ Kevin C. Tang 2017-01-23 /s/ Kevin C. Tang, Managing Member 2017-01-23 /s/ Kevin C. Tang, as Managing Member of Tang Capital Management, LLC, General Partner 2017-01-23