X0304 4 2012-02-01 0 0001103390 Ardea Biosciences, Inc./DE RDEA 0001178579 TANG KEVIN C 4747 EXECUTIVE DRIVE SUITE 510 SAN DIEGO CA 92121 1 0 1 0 0001232621 TANG CAPITAL MANAGEMENT LLC 4747 EXECUTIVE DRIVE SUITE 510 SAN DIEGO CA 92121 0 0 1 0 0001191935 TANG CAPITAL PARTNERS LP 4747 EXECUTIVE DRIVE SUITE 510 SAN DIEGO CA 92121 0 0 1 0 Common Stock 2012-02-01 4 P 0 426470 17.00 A 3733582 I By LP Common Stock 67052 I As Trustee Common Stock 15089 D The securities are held by Tang Capital Partners, LP. Kevin C. Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein. The securities are owned by Kevin C. Tang as custodian for his minor children and as Trustee of the Tang Advisors, LLC Profit Sharing Plan, for which Mr. Tang serves as Trustee and in which he is a participant. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein. The securities are owned by Kevin C. Tang's IRA. /s/ Kevin C. Tang 2012-02-03 /s/ Kevin C. Tang, Managing Member 2012-02-03 Kevin C. Tang, as Managing Member of Tang Capital Management, LLC, General Partner 2012-02-03