X0303 5 2010-12-31 0 0 0 0001103390 Ardea Biosciences, Inc./DE RDEA 0001178579 TANG KEVIN C 4401 EASTGATE MALL SAN DIEGO CA 92121 1 0 1 0 0001232621 TANG CAPITAL MANAGEMENT LLC 4401 EASTGATE MALL SAN DIEGO CA 92121 0 0 1 0 0001191935 TANG CAPITAL PARTNERS LP 4401 EASTGATE MALL SAN DIEGO CA 92121 0 0 1 0 Common Stock 3095112 I By LP Common Stock 2010-11-15 5 G 0 225000 0.00 D 67052 I As Trustee Common Stock 15089 D The securities are held by Tang Capital Partners, LP. Kevin C. Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein. The gifted securities were held by Kevin C. Tang, as Trustee of the Tang Family Trust. The gifted securities were donated to a charitable foundation. The remaining securities are owned by Kevin C. Tang as custodian for his minor children and as Trustee of the Tang Advisors, LLC Profit Sharing Plan, for which Mr. Tang serves as Trustee and in which he is a participant. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein. The securities are owned by Kevin C. Tang's IRA. /s/ Kevin C. Tang 2011-01-24 /s/ Kevin C. Tang, Managing Member 2011-01-24 /s/ Kevin C. Tang, as Managing Member of Tang Capital Management, LLC, General Partner 2011-01-24