X0303 4 2008-09-17 0 0001103390 Ardea Biosciences, Inc./DE RDEA 0001178579 TANG KEVIN C 4401 EASTGATE MALL SAN DIEGO CA 92121 1 0 1 0 0001232621 TANG CAPITAL MANAGEMENT LLC 4401 EASTGATE MALL SAN DIEGO CA 92121 0 0 1 0 0001191935 TANG CAPITAL PARTNERS LP 4401 EASTGATE MALL SAN DIEGO CA 92121 0 0 1 0 Common Stock 2008-09-17 4 X 0 5700 0.00 A 3163460 I By LP Common Stock 196294 I As Trustee Common Stock 15089 D Common Stock Warrant (Right to Buy) 10.85 2008-09-17 4 X 0 24000 0.00 D 2003-10-10 2008-10-10 Common Stock 24000 0 I By LP Tang Capital Partners, LP exercised, in full, a Warrant to purchase 24,000 shares of Common Stock, pursuant to the Warrant's Net Issue Exercise provision. The Warrant had an Exercise Price of $10.85 per share and based on the terms of the Net Issue Exercise provision, the Fair Market Value of the Common Stock used in the Net Issue Exercise calculation was $14.23 per share. The Net Issue Exercise resulted in Tang Capital Partners, LP recieving 5,700 shares of Common Stock for no cash consideration. The securities are held by Tang Capital Partners, LP. Kevin C. Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein. The securities are owned by Kevin C. Tang as custodian for his minor children, as Trustee of the Tang Family Trust and as Trustee of the Tang Advisors, LLC Profit Sharing Plan, for which Mr. Tang serves as Trustee and in which he is a participant. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein. The securities are owned by Kevin C. Tang's IRA. /s/ Kevin C. Tang 2008-09-19 /s/ Kevin C. Tang, Managing Member 2008-09-19 /s/ Kevin C. Tang, as Managing Member of Tang Capital Management, LLC, General Partner 2008-09-19