X0202 4 2008-05-07 0 0001103390 Ardea Biosciences, Inc./DE RDEA 0001178579 TANG KEVIN C 4401 EASTGATE MALL SAN DIEGO CA 92121 1 0 1 0 0001232621 TANG CAPITAL MANAGEMENT LLC 4401 EASTGATE MALL SAN DIEGO CA 92121 0 0 1 0 0001191935 TANG CAPITAL PARTNERS LP 4401 EASTGATE MALL SAN DIEGO CA 92121 0 0 1 0 Common Stock 2008-05-07 4 C 0 852308 A 3157760 I By LP Common Stock 196294 I As Trustee Common Stock 15089 D Series A Convertible Preferred Stock 2008-05-07 4 C 0 162 0.00 D 2003-05-01 Common Stock 852308 0 I By LP Each share of Series A Convertible Preferred Stock was convertible into a number of shares of common stock equal to $10,000 divided by $1.90072. Includes 2,166 shares and 2,488 shares issued to Tang Capital Partners, LP as dividends on shares of the issuer's Series A Convertible Preferred Stock on 12/31/07 and 3/31/08, respectively. The securities are held by Tang Capital Partners, LP. Kevin C. Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. Mr. Tang disclaims beneficial ownership of the securities except to the extent of his pecuniary interest therein. The securities are owned by Kevin C. Tang as custodian for his minor children, as Trustee of the Tang Family Trust and as Trustee of the Tang Advisors, LLC Profit Sharing Plan, for which Mr. Tang serves as Trustee and in which he is a participant. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein. The securities are owned by Kevin C. Tang's IRA. Subject to its terms and conditions, each share of Series A Convertible Preferred Stock automatically converts into shares of common stock on the tenth day after the day that the closing sale price of the issuer's common stock on the NASDAQ Global Market (formerly the NASDAQ National Market) has reached at least $8.28 and has remained at such level for 20 consecutive trading days. This automatic conversion occurred on May 7, 2008. The Series A Convertible Preferred Stock did not have an expiration date. /s/ Kevin C. Tang 2008-05-16 Kevin C. Tang, Managing Member 2008-05-16 Kevin C. Tang, as Managing Member of Tang Capital Management, LLC, General Partner 2008-05-16