Share-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Sep. 30, 2024
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 88,125	$ 59,760	$ 220,279	$ 177,855
Income tax benefit from share-based compensation expense	(16,619)	(12,190)	(38,412)	(25,218)
Total share-based compensation expense, net of tax	71,506	47,570	181,867	152,637
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	61,295	37,101	143,968	112,451
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	21,767	18,927	63,348	55,030
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 5,063	$ 3,732	$ 12,963	$ 10,374