Share-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2025

Share-Based Payment Arrangement [Abstract]

Schedule of Share-Based Compensation Expense

Share-based compensation expense related to RSUs, PRSUs, share options and grants under our ESPP was as follows (in thousands): 

	Three Months Ended September 30,				Nine Months Ended September 30,
	2025		2024		2025		2024
Selling, general and administrative	$	61,295	$	37,101	$	143,968	$	112,451
Research and development	21,767		18,927		63,348		55,030
Cost of product sales	5,063		3,732		12,963		10,374
Total share-based compensation expense, pre-tax	88,125		59,760		220,279		177,855
Income tax benefit from share-based compensation expense	(16,619)		(12,190)		(38,412)		(25,218)
Total share-based compensation expense, net of tax	$	71,506	$	47,570	$	181,867	$	152,637