Share-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 64,501	$ 56,654	$ 132,154	$ 118,095
Income tax benefit from share-based compensation expense	(12,259)	(9,629)	(21,793)	(13,028)
Total share-based compensation expense, net of tax	52,242	47,025	110,361	105,067
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	40,999	35,137	82,673	75,350
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	20,651	17,272	41,581	36,103
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 2,851	$ 4,245	$ 7,900	$ 6,642