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Share-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2025
Share-Based Payment Arrangement [Abstract]  
Schedule of Share-Based Compensation Expense
Share-based compensation expense related to RSUs, PRSUs, grants under our ESPP and share options was as follows (in thousands): 
Three Months Ended
June 30,		Six Months Ended
June 30,
2025202420252024
Selling, general and administrative$40,999 $35,137 $82,673 $75,350 
Research and development20,651 17,272 41,581 36,103 
Cost of product sales2,851 4,245 7,900 6,642 
Total share-based compensation expense, pre-tax64,501 56,654 132,154 118,095 
Income tax benefit from share-based compensation expense(12,259)(9,629)(21,793)(13,028)
Total share-based compensation expense, net of tax$52,242 $47,025 $110,361 $105,067