CONSOLIDATED STATEMENTS OF INCOME (LOSS) - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenues:
Total revenues	$ 4,068,950	$ 3,834,204	$ 3,659,374
Operating expenses:
Cost of product sales (excluding amortization of acquired developed technologies)	445,713	435,577	540,517
Selling, general and administrative	1,385,294	1,343,105	1,416,967
Research and development	884,000	849,658	590,453
Intangible asset amortization	627,313	608,284	599,169
Acquired in-process research and development	10,000	19,000	444,148
Intangible asset impairment charge	0	0	133,648
Total operating expenses	3,352,320	3,255,624	3,724,902
Income (loss) from operations	716,630	578,580	(65,528)
Interest expense, net	(238,097)	(289,438)	(288,242)
Foreign exchange gain (loss)	(8,182)	8,787	(19,014)
Income (loss) before income tax benefit and equity in loss of investees	470,351	297,929	(372,784)
Income tax benefit	(91,429)	(119,912)	(158,645)
Equity in loss of investees	1,660	3,009	9,921
Net income (loss)	$ 560,120	$ 414,832	$ (224,060)
Net income (loss) per ordinary share:
Basic (in dollars per share)	$ 9.06	$ 6.55	$ (3.58)
Diluted (in dollars per share)	$ 8.65	$ 6.10	$ (3.58)
Weighted-average ordinary shares used in per share calculations - basic (in shares)	61,838	63,291	62,539
Weighted-average ordinary shares used in per share calculations - diluted (in shares)	66,007	72,066	62,539
Product sales, net
Revenues:
Total revenues	$ 3,821,164	$ 3,736,943	$ 3,641,429
Royalties and contract revenues
Revenues:
Total revenues	$ 247,786	$ 97,261	$ 17,945