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Insider Trading Arrangements

3 Months Ended

12 Months Ended

Dec. 31, 2024

The following is a summary of the material terms of the contracts, instructions or written plans for the purchase or sale of the Company’s securities adopted or terminated by our officers (as defined in Rule 16a-1(f) under the Securities Exchange Act of 1934, as amended) and directors during the quarter ended December 31, 2024:

Type of Trading Arrangement

Name and Position

Date

Action

Rule 10b5-1*

Expiration Date

Total Ordinary Shares to be Sold

Robert Iannone

December 6, 2024

Termination(1)

March 7, 2025

10,681

Robert Iannone

December 6, 2024

Adoption(1)

December 6, 2025

12,625

Executive Vice President, Global Head of Research and Development, Chief Medical Officer

(1) Represents the modification, as described in Rule 10b5-1(c)(1)(iv) under the Exchange Act, of a written plan initially adopted on March 7, 2024 that was intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act.

* Contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

Non-Rule 10b5-1 Arrangement Adopted

false

Non-Rule 10b5-1 Arrangement Terminated

false

Robert Iannone [Member]

Trading Arrangements, by Individual

Arrangement Duration

365 days

Robert Iannone March 2024 Modified Plan [Member] | Robert Iannone [Member]

Trading Arrangements, by Individual

Name

Robert Iannone