CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Operating activities
Net income (loss)	$ 560,120	$ 414,832	$ (224,060)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Intangible asset amortization	627,313	608,284	599,169
Share-based compensation	248,045	226,841	221,996
Acquisition accounting inventory fair value step-up adjustment	135,014	151,446	273,392
Depreciation	32,754	30,412	30,302
Provision for losses on accounts receivable and inventory	27,758	11,113	14,537
Non-cash interest expense	21,973	22,378	37,973
Acquired in-process research and development	10,000	19,000	444,148
Deferred tax benefit	(208,327)	(260,217)	(292,251)
Impairment of property, plant and equipment	0	61,014	0
Intangible asset impairment charge	0	0	133,648
Loss on disposal of a business	0	0	37,704
Other non-cash transactions	17,978	11,343	(14,486)
Changes in assets and liabilities:
Accounts receivable	(21,115)	(51,883)	(90,135)
Inventories	(45,542)	(13,420)	(49,642)
Prepaid expenses and other current assets	10,574	(126,179)	35,788
Operating lease assets	17,111	14,948	14,769
Other non-current assets	(49,820)	(15,884)	(24,038)
Accounts payable	(20,073)	9,603	(11,225)
Accrued liabilities	86,159	(23,245)	165,991
Income taxes payable	(14,742)	25,220	(1,692)
Deferred revenue	0	(463)	(2,093)
Operating lease liabilities, less current portion	(24,741)	(16,965)	(16,422)
Other non-current liabilities	(14,531)	(6,171)	(11,396)
Net cash provided by operating activities	1,395,908	1,092,007	1,271,977
Investing activities
Acquisition of investments	(1,305,125)	(390,100)	(61,036)
Purchases of property, plant and equipment	(38,070)	(23,962)	(29,046)
Acquired in-process research and development	(10,000)	(19,000)	(444,148)
Proceeds from maturity of investments	845,000	270,000	60,000
Acquisition of intangible assets	0	0	(25,000)
Proceeds from sale of a business	0	0	53,000
Net cash used in investing activities	(508,195)	(163,062)	(446,230)
Financing activities
Net proceeds from issuance of 2030 Notes	980,767	0	0
Proceeds from employee equity incentive and purchase plans	20,647	46,459	98,020
Payment of debt modification costs	(5,716)	0	0
Repayments of long-term debt	(31,000)	(31,000)	(582,014)
Payment of employee withholding taxes related to share-based awards	(57,753)	(50,952)	(45,443)
Share repurchases	(311,429)	(269,761)	(54)
Repayment of 2024 Notes	(575,000)	0	0
Net cash provided by (used in) financing activities	20,516	(305,254)	(529,491)
Effect of exchange rates on cash and cash equivalents	(1,675)	1,137	(6,222)
Net increase in cash and cash equivalents	906,554	624,828	290,034
Cash and cash equivalents, at beginning of period	1,506,310	881,482	591,448
Cash and cash equivalents, at end of period	2,412,864	1,506,310	881,482
Supplemental disclosure of cash flow information:
Cash paid for interest	314,822	333,112	270,671
Cash paid for income taxes, net of refunds	$ 114,907	$ 177,880	$ 94,681