Revenues - Summary of Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Disaggregation of Revenue [Line Items]
Total revenues	$ 932,878	$ 751,811	$ 1,746,599	$ 1,359,392
United States
Disaggregation of Revenue [Line Items]
Total revenues	858,340	690,900	1,598,923	1,239,192
Europe
Disaggregation of Revenue [Line Items]
Total revenues	60,779	47,270	121,807	94,503
All other
Disaggregation of Revenue [Line Items]
Total revenues	13,759	13,641	25,869	25,697
Product sales, net
Disaggregation of Revenue [Line Items]
Total revenues	928,300	748,340	1,738,137	1,351,871
Total Oncology
Disaggregation of Revenue [Line Items]
Total revenues	229,825	163,787	426,629	341,963
Total Oxybate
Disaggregation of Revenue [Line Items]
Total revenues	504,446	458,346	938,023	869,312
Xyrem
Disaggregation of Revenue [Line Items]
Total revenues	269,421	334,182	516,918	669,732
Xywav
Disaggregation of Revenue [Line Items]
Total revenues	235,025	124,164	421,105	199,580
Total Neuroscience
Disaggregation of Revenue [Line Items]
Total revenues	696,843	581,912	1,308,933	1,004,484
Epidiolex/Epidyolex
Disaggregation of Revenue [Line Items]
Total revenues	175,289	109,481	333,182	109,481
Sunosi
Disaggregation of Revenue [Line Items]
Total revenues	12,966	12,124	28,844	23,730
Sativex
Disaggregation of Revenue [Line Items]
Total revenues	4,142	1,961	8,884	1,961
Zepzelca
Disaggregation of Revenue [Line Items]
Total revenues	68,285	55,924	127,623	110,258
Rylaze
Disaggregation of Revenue [Line Items]
Total revenues	72,954	0	127,174	0
Vyxeos
Disaggregation of Revenue [Line Items]
Total revenues	33,890	31,453	67,647	64,608
Defitelio/defibrotide
Disaggregation of Revenue [Line Items]
Total revenues	54,696	48,096	104,185	97,715
Erwinaze/Erwinase
Disaggregation of Revenue [Line Items]
Total revenues	0	28,314	0	69,382
Other
Disaggregation of Revenue [Line Items]
Total revenues	1,632	2,641	2,575	5,424
Royalties and contract revenues
Disaggregation of Revenue [Line Items]
Total revenues	$ 4,578	$ 3,471	$ 8,462	$ 7,521