Condensed Consolidated Statements of Income (Loss) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Total revenues	$ 932,878	$ 751,811	$ 1,746,599	$ 1,359,392
Operating expenses:
Cost of product sales (excluding amortization of acquired developed technologies)	124,208	119,194	239,492	159,383
Selling, general and administrative	366,473	429,031	675,286	689,539
Research and development	139,047	132,696	269,028	209,269
Intangible asset amortization	148,456	140,480	320,550	208,672
Acquired in-process research and development	69,148	0	69,148	0
Total operating expenses	847,332	821,401	1,573,504	1,266,863
Income (loss) from operations	85,546	(69,590)	173,095	92,529
Interest expense, net	(63,189)	(69,420)	(133,873)	(96,796)
Foreign exchange gain (loss)	(1,343)	2,950	(11,883)	3,893
Income (loss) before income tax expense (benefit) and equity in loss (gain) of investees	21,014	(136,060)	27,339	(374)
Income tax expense (benefit)	(16,112)	228,621	(15,576)	246,640
Equity in loss (gain) of investees	2,461	(1,365)	6,603	(5,530)
Net income (loss)	$ 34,665	$ (363,316)	$ 36,312	$ (241,484)
Net income (loss) per ordinary share:
Basic (in dollars per share)	$ 0.56	$ (6.11)	$ 0.58	$ (4.17)
Diluted (in dollars per share)	$ 0.55	$ (6.11)	$ 0.57	$ (4.17)
Weighted-average ordinary shares used in per share calculations - basic (in shares)	62,436	59,448	62,152	57,966
Weighted-average ordinary shares used in per share calculations - diluted (in shares)	63,431	59,448	63,171	57,966
Product sales, net
Revenues:
Total revenues	$ 928,300	$ 748,340	$ 1,738,137	$ 1,351,871
Royalties and contract revenues
Revenues:
Total revenues	$ 4,578	$ 3,471	$ 8,462	$ 7,521